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Adapalene

Also indexed as: Differin®

Adapalene is a vitamin A–related drug that is applied to the skin to treat acne.

Interaction with Foods and Other Compounds

Topical application of adapalene may cause skin irritation in some individuals. This irritation can be worsened when alcohol, astringents, spices, and lime are also applied to the area.1 Sensitive individuals should use caution when using adapalene and other topical compounds.

Summary of Interactions for Adapalene

Depletion or interference None known
Adverse interaction None known
Side effect reduction/prevention None known
Supportive interaction None known
Reduced drug absorption/bioavailability None known

For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

References:

1. Sifton DW, ed. Physicians Desk Reference. Montvale. NJ: Medical Economics Company, Inc., 2000, 1104–5.