.
Buspirone is used to treat anxiety disorders and less commonly to treat symptoms of premenstrual syndrome.
Interactions with Herbs
Kava(Piper
methysticum)
Kava is an herb used to treat anxiety disorder. Although no direct interactions have been
reported, buspirone should not be used together with kava unless with medical supervision.
Interactions with Foods and Other Compounds
Food
Food reduces metabolism of buspirone, increasing serum buspirone levels.1 Buspirone
should be taken at the same time each day, always with food or always without food.
Alcohol
Buspirone may cause drowsiness and dizziness.2 Alcohol may compound these effects
and increase the risk of accidental injury. To prevent problems, people taking buspirone
should avoid alcohol.
Summary of Interactions for Buspirone
| Depletion or interference | None known |
|---|---|
| Adverse interaction | Kava |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Gammans RE, Mayol RF, LaBudde JA. Metabolism and disposition of buspirone. Am J Med 1986;80:41–51.
2. Threlkeld DS, ed. Central Nervous System Drugs, Antianxiety Agents, Miscellaneous Agents. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, May 1990, 262–c.
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