.
Cisapride is a gastrointestinal stimulant drug used to treat people with nighttime heartburn due to reflux of stomach acid into the esophagus. It is also used to increase movement of gastrointestinal contents in conditions of lack of spontaneous gastrointestinal movement.
Interactions with Herbs
Menthol-containing herbs
People with esophageal reflux should avoid use of menthol-containing herbs, such as peppermint; the volatile oils in these plants may decrease the
pressure in the lower esophageal sphincter and make the reflux worse.1
Interactions with Foods and Other Compounds
Alcohol
Alcohol consumption is associated with nighttime heartburn and may interfere with cisapride
therapy.2 Alcohol causes sleepiness, and cisapride may intensify this
effect,3 increasing the risk of accidental injury. People taking cisapride should
avoid alcohol.
Tobacco
Smoking is associated with nighttime heartburn and may interfere with cisapride
therapy.4 Smokers taking cisapride may benefit from reducing or quitting
smoking.
Summary of Interactions for Cisapride
| Depletion or interference | Menthol-containing herbs such as peppermint |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | Tobacco |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Sigmund CJ, McNally EF. The action of a carminative on the lower esophageal sphincter. Gastroenterol 1969;56:13–8.
2. Threlkeld DS, ed. Gastrointestinal Drugs, GI Stimulants, Cisapride. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Nov 1998, 308b–8c.
3. Threlkeld DS, ed. Gastrointestinal Drugs, GI Stimulants, Cisapride. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Nov 1998, 308b–8c.
4. Threlkeld DS, ed. Gastrointestinal Drugs, GI Stimulants, Cisapride. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Nov 1998, 308b–8c.
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