.
Donepezil is used to treat memory loss associated with Alzheimer’s disease.
Interactions with Dietary Supplements
Huperzine-A
Further studies are needed to determine the long-term safety of huperizine A. Until more is
known about it’s actions in the body, it is best to avoid using it together with
donepezil, which also prevents the breakdown of acetylcholine.
Summary of Interactions for Donepezil
| Depletion or interference | None known |
|---|---|
| Adverse interaction | Huperzine-A* |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
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