.
Combination drugs: Cozaar-Comp®, Hyzaar®
Losartan is used alone or in combination with hydrochlorothiazide (Hyzaar®) in the treatment of high blood pressure. It is a type of drug called an angiotensin II receptor antagonist.
Interactions with Dietary Supplements
Potassium
Losartan has caused significant increases in blood potassium levels.1 Potassium
supplements, potassium-containing salt substitutes (No Salt®, Morton Salt
Substitute®, and others), and even high-potassium foods (primarily fruit) should be avoided by those taking losartan, unless
directed otherwise by their doctor.
Interactions with Foods and Other Compounds
Food
The intestinal absorption of losartan may be reduced up to 10% if taken with food.2
Although this is a minor reduction, losartan should be taken an hour before or two hours after
food for maximum effectiveness.
Summary of Interactions for Losartan
| Depletion or interference | None known |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
| Other (see text) | Potassium |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Perazella MA. Drug-induced hyperkalemia: Old culprits and new offenders. Am J Med 2000;109:307–14 [review].
2. Sifton DW, ed. Physicians Desk Reference. Montvale, NJ: Medical Economics Company, Inc., 2000, 1769–72.
Copyright © 2002 VitaminLore, Inc. All rights reserved. www.VitaminLore.com
Please read the disclaimer about the limitations of the information provided here. Do NOT rely solely on the information in this article.
Click here Buy Vitamins and Nutritional Supplements at very low prices..
Buy Brand name Vitamins for less from www.vitaminlore.com. Safetychecker.
The information presented in VitaminLore is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.