.
Nefazodone is a drug used to treat people with depression.
Interactions with Herbs
Digitalis (Digitalis lanata, Digitalis
purpurea)
Digitalis refers to a family of plants commonly called foxglove that contain digitalis
glycosides, chemicals with actions and toxicities similar to the prescription drug digoxin.
Nefazodone increased serum digoxin levels in a three-way crossover study of 18 healthy men.1 No interactions between nefazodone and digitalis have been reported. Until more is known, nefazodone and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use.
St. John’s
wort (Hypericum perforatum)
Although there have been no interactions reported in the medical literature, it is best to
avoid using nefazodone with St. John’s wort unless you are under the supervision of a
qualified healthcare professional.
Interactions with Foods and Other Compounds
Food
Nefazodone may be taken with or without food.2
Alcohol
People taking nefazodone are advised to avoid alcohol.3
Summary of Interactions for Nefazodone
| Depletion or interference | None known |
|---|---|
| Adverse interaction | St. John’s wort* |
| Side effect reduction/prevention | None known |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
| Other (see text) | Digitalis |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Dockens RC, Greene DS, Barbhaiya RH. Assessment of pharmacokinetic and pharmacodynamic drug interactions between nefazodone and digoxin in healthy male volunteers. J Clin Pharmacol 1996;36:160–7.
2. Dockens RC, Greene DS, Barbhaiya RH. The lack effect of food on the bioavailability of nefazodone tablets. Biopharm Drug Dispos 1996;17:135–43.
3. Threlkeld DS, ed. Central Nervous System Drugs, Antidepressants, Trazodone. In Facts and Comparisons Drug Information. St. Louis, MO: Facts and Comparisons, Mar 1995, 263i–3k.
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