.
Stavudine is used to treat human immunodeficiency virus (HIV) infections. It is in a class of drugs known as antivirals.
Interactions with Dietary Supplements
Vitamin B1
(thiamine)
A 30-year-old woman who was taking stavudine developed a rare side effect called lactic
acidosis, which was successfully treated with intravenous thiamine.1 Controlled
studies are needed to determine whether lactic acidosis might be prevented if people taking
stavudine supplement with vitamin B1. Until more information is available, some health
practitioners may recommend supplemental vitamin B1 to individuals taking stavudine.
Summary of Interactions for Stavudine
| Depletion or interference | None known |
|---|---|
| Adverse interaction | None known |
| Side effect reduction/prevention | Vitamin B1* |
| Supportive interaction | None known |
| Reduced drug absorption/bioavailability | None known |
For the convenience of the reader, the information in the summary is categorized as follows: “Depletion or interference” indicates the drug may deplete or interfere with the absorption or function of the supplement or herb. “Adverse interaction” indicates that the supplement or herb used together with the drug may result in undesirable effects. “Side effect reduction/prevention” indicates the supplement or herb may reduce the likelihood and/or severity of a potential side effect caused by the drug. “Supportive interaction” indicates the supplement or herb may support or aid the function of the drug. “Reduced drug absorption/bioavailability” indicates that the supplement or herb may decrease the absorption and/or activity of the drug in the body. An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
References:
1. Schramm C, Wanitschke R, Galle PR. Thiamin for the treatment of nucleoside analogue-induced severe lactic acidosis. Eur J Anaesthesiol 1999;16:733–5.
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The information presented in VitaminLore is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.