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Alanine

What does it do? Alanine is a nonessential amino acid used by the body to build proteins. Alanine is present in prostate fluid, and it may play a role in supporting prostate health. One study, involving 45 men with benign prostatic hyperplasia, found that 780 mg of alanine per day for two weeks and then 390 mg for the next two and a half months, taken in combination with equal amounts of the amino acids glycine and glutamic acid, reduced symptoms of benign prostatic hyperplasia;1 this work has been independently confirmed.2

Where is it found? As with the other amino acids, excellent sources of alanine include meat and poultry, fish, eggs, and dairy products. Some protein-rich plant foods also supply alanine.

Alanine has been used in connection with the following condition (refer to the individual health concern for complete information):

Rating Health Concerns
2Stars Benign prostatic hyperplasia (in combination with glycine and glutamic acid)
3Stars Reliable and relatively consistent scientific data showing a substantial health benefit.
2Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
1Star An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.

Who is likely to be deficient? Since alanine is synthesized in the body and is also provided by most foods that are sources of protein, deficiencies are unlikely to occur.3

How much is usually taken? Most people do not need to supplement with alanine; for those who do use this amino acid as a supplement, appropriate amounts should be determined with the consultation of a physician.

Are there any side effects or interactions? Alanine is free of side effects for the vast majority of people who take it; however, people with kidney or liver disease should not consume high intakes of amino acids without consulting a healthcare professional.

At the time of writing, there were no well-known drug interactions with alanine.

References:

1. Damrau F. Benign prostatic hypertrophy: Amino acid therapy for symptomatic relief. J Am Geriatrics Soc 1962;10(5):426–30.

2. Feinblatt HM, Gant JC. Palliative treatment of benign prostatic hypertrophy. Value of glycine-alanine-glutamic acid combination. J Maine Med Assoc 1958;March.

3. Zello GA, Wykes LF, Ball RO, et al. Recent advances in methods of assessing dietary amino acid requirements for adult humans. J Nutr 1995;125:2907–15.